Articular cartilage collagen and proteoglycans their functional interdependency
نویسندگان
چکیده
منابع مشابه
Biochemistry of articular cartilage. Nature of proteoglycans and collagen of articular cartilage and their role in ageing and in osteoarthrosis.
The cartilage which covers the articular surfaces of bones of vertebrate animals has two main functions: the limitation of stress applied to the bone extremities and the provision of the smooth surfaces necessary for the joint to function as an efficient bearing (Kempson, Spivey, Freeman, and Swanson, 1969). To meet these functional demands the cartilage exhibits a combination of physical prope...
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The extracellular framework and two-thirds of the dry mass of adult articular cartilage are polymeric collagen. Type II collagen is the principal molecular component in mammals, but collagens III, VI, IX, X, XI, XII and XIV all contribute to the mature matrix. In developing cartilage, the core fibrillar network is a cross-linked copolymer of collagens II, IX and XI. The functions of collagens I...
متن کاملCollagen of articular cartilage
The extracellular framework and two-thirds of the dry mass of adult articular cartilage are polymeric collagen. Type II collagen is the principal molecular component in mammals, but collagens III, VI, IX, X, XI, XII and XIV all contribute to the mature matrix. In developing cartilage, the core fibrillar network is a cross-linked copolymer of collagens II, IX and XI. The functions of collagens I...
متن کاملThe heterogeneity of cartilage proteoglycans. Isolation of different types of proteoglycans from bovine articular cartilage.
Proteoglycans, proteins, and glycoproteins were extracted from femoral condyle (FC) and metacarpalphalangeal (MP) articular cartilages and fractionated by sequential density gradient sedimentation under dissociative conditions. The major high density proteoglycan (PG-I) accounted for 74% of the total proteoglycan extracted from the MP cartilage and 79% of that from the femoral condyle. These pr...
متن کاملHierarchical Catabolism of Collagen Associated Proteoglycans in in Vitro Models of Progressive Articular Cartilage Degradation
Introduction. Degradation of articular cartilage is a central feature of joint diseases. Proteolysis of the two major structural components of the extracellular matrix of articular cartilage, namely aggrecan and type II collagen, disrupts the mechanical integrity of the tissue leading eventually to erosion and exposure of subchondral bone. Depletion of aggrecan is one of the earliest events in ...
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ژورنال
عنوان ژورنال: Arthritis & Rheumatism
سال: 1983
ISSN: 0004-3591,1529-0131
DOI: 10.1002/art.1780260909